血清IgM随幽门螺杆菌血清学阳性呈下降趋势。
Downward shift in serum IgM with Helicobacter pylori seropositivity.
作者信息
Dobbs R J, Dobbs S M, Charlett A, Weller C
机构信息
Therapeutics in the Elderly, Research Group, Northwick Park and St Mark's Hospitals, Harrow, HA1 3UJ, UK.
出版信息
J Infect. 2000 Nov;41(3):240-4. doi: 10.1053/jinf.2000.0741.
OBJECTIVE
To determine whether Helicobacter pylori infection is associated with premature immune ageing, with respect to circulating immunoglobulins.
METHODS
Serum immunoglobulin classes and H. pylori anti-urease antibody were measured in 205 subjects (aged 30-89 years), obeying inclusion/exclusion criteria.
RESULTS
IgM decreased (P<0.001) by 0.9 (95% C.I. 0.3, 1.4)% per year, H. pylori seropositivity having an effect equivalent to 25 years of ageing (P<0.02). IgA increased by 0.5 (0.1, 0.8)% per year (P<0.007), IgG being unaffected by age. Seropositivity had no effect on IgA or IgG.
CONCLUSIONS
Increasing age and H. pylori seropositivity are each associated with a downward shift in circulating IgM. If clinical extrapolation is justified, H. pylori eradication may be important in combating susceptibility to infection in old age.
目的
就循环免疫球蛋白而言，确定幽门螺杆菌感染是否与免疫早衰相关。
方法
对205名符合纳入/排除标准的受试者（年龄30 - 89岁）测定血清免疫球蛋白类别及幽门螺杆菌抗尿素酶抗体。
结果
IgM每年下降（P<0.001）0.9（95%可信区间0.3，1.4）%，幽门螺杆菌血清阳性的影响相当于25年的衰老（P<0.02）。IgA每年增加0.5（0.1，0.8）%（P<0.007），IgG不受年龄影响。血清阳性对IgA或IgG无影响。
结论
年龄增长和幽门螺杆菌血清阳性均与循环IgM水平下降有关。如果临床推断合理，根除幽门螺杆菌对于对抗老年人的感染易感性可能很重要。
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