不稳定型心绞痛和心肌梗死患者人体血小板中的酶促氧化剂和抗氧化剂

Enzymatic oxidant and antioxidants of human blood platelets in unstable angina and myocardial infarction.

作者信息

Pandey N R, Kaur G, Chandra M, Sanwal G G, Misra M K

机构信息

Department of Biochemistry, Lucknow University, 226 007, Lucknow, India.

出版信息

Int J Cardiol. 2000 Oct;76(1):33-8. doi: 10.1016/s0167-5273(00)00344-2.

DOI:10.1016/s0167-5273(00)00344-2

PMID:11121594

Abstract

In ischaemic heart conditions we report a remarkable increase in platelet xanthine oxidase activity and rise in the levels of malondialdehyde (MDA) with concomitant decrease in the activities of free radical scavenging enzymes - superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. The increased levels of free radical generating system and MDA and lowered levels of free radical scavenging systems seem to have critical role in ischaemic heart conditions.

摘要

在缺血性心脏病中，我们发现血小板黄嘌呤氧化酶活性显著增加，丙二醛（MDA）水平升高，同时自由基清除酶——超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性降低。自由基生成系统和MDA水平的升高以及自由基清除系统水平的降低似乎在缺血性心脏病中起关键作用。