Dunn J F, Grinberg O, Roche M, Nwaigwe C I, Hou H G, Swartz H M
NMR Research Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
J Cereb Blood Flow Metab. 2000 Dec;20(12):1632-5. doi: 10.1097/00004647-200012000-00002.
Factors regulating cerebral tissue PO2 (PtO2) are complex. With the increased use of clinical PtO2 monitors, it has become important to elucidate these mechanisms. The authors are investigating a new methodology (electron paramagnetic resonance oximetry) for use in monitoring cerebral PtO2 in awake animals over time courses of weeks. The authors used this to study cerebral PtO2 in rats during chronic acclimation to hypoxia predicting that such acclimation would cause an increase in PtO2 because of increases that occur in capillary density and oxygen carrying capacity. The average PtO2 between 7 and 21 days was increased by 228% over controls.
调节脑组织氧分压（PtO2）的因素很复杂。随着临床PtO2监测仪的使用增加，阐明这些机制变得很重要。作者正在研究一种新方法（电子顺磁共振血氧测定法），用于在数周的时间过程中监测清醒动物的脑PtO2。作者用此方法研究大鼠在慢性适应低氧过程中的脑PtO2，预测这种适应会因毛细血管密度和携氧能力的增加而导致PtO2升高。与对照组相比，7至21天期间的平均PtO2增加了228%。
