Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.

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作者信息

Zhang N, Wu B, Powell D, Wissner A, Floyd M B, Kovacs E D, Toral-Barza L, Kohler C

机构信息

Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA.

出版信息

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2825-8. doi: 10.1016/s0960-894x(00)00580-1.

DOI:10.1016/s0960-894x(00)00580-1

PMID:11133101

Abstract

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells.

摘要

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