镁和MK-801在两种神经性疼痛实验模型中具有相似的作用。

Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain.

作者信息

Begon S, Pickering G, Eschalier A, Dubray C

机构信息

INSERM EPI 9904, Pharmacologie Fondamentale et Clinique de la Douleur, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, B.P. 38, 63001 Clermont-Ferrand, Cedex 1, France.

出版信息

Brain Res. 2000 Dec 29;887(2):436-9. doi: 10.1016/s0006-8993(00)03028-6.

DOI:10.1016/s0006-8993(00)03028-6

PMID:11134637

Abstract

Considering that magnesium and non-competitive NMDA receptor antagonists inhibit the opening of the channel linked to the NMDA receptor, we assessed their effects on mechanical hyperalgesia in two animal models of neuropathic pain (rats with a sciatic nerve ligature and diabetic rats). Our data show that magnesium reverses the hyperalgesia, as does MK-801. These results suggest that magnesium could be an alternative for the treatment of neuropathic pain in patients.

摘要

鉴于镁和非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂可抑制与NMDA受体相连通道的开放，我们在两种神经性疼痛动物模型（坐骨神经结扎大鼠和糖尿病大鼠）中评估了它们对机械性痛觉过敏的影响。我们的数据表明，镁和MK-801一样，可逆转痛觉过敏。这些结果提示，镁可能是治疗患者神经性疼痛的一种替代药物。