Yum M K, Park E Y, Kim C R, Hwang J H
Department of Pediatric Cardiology, Hanyang University School of Medicine, 17 Haengdang-dong Sungdong-ku, 133-792, Seoul, South Korea.
Eur J Obstet Gynecol Reprod Biol. 2001 Jan;94(1):51-8. doi: 10.1016/s0301-2115(00)00314-6.
To determine whether irregularity, and short- and long-term fractal correlation reflecting smoothness of heart rate behavior are changed in intrauterine growth restricted fetuses.
Fetal heart rate data of 192 normal fetuses and 86 intrauterine growth restricted fetuses between 31 and 42 weeks of gestation were studied. Approximate entropy to quantify irregularity, and short-term (< or =80 beats, alpha1) and long-term (>80 beats, alpha2) fractal scaling exponents to quantify the short- and long-term fractal correlation were calculated.
In the intrauterine growth restricted fetuses, the approximate entropy was significantly lower (P<0.001). The alpha2 value was significantly higher (P=0.0001) than in the normal fetuses, which performed better (F=34.2, P<0.0001) than other heart rate variability indexes in differentiating the intrauterine growth restricted fetuses from the normal fetuses in stepwise discriminant analysis.
Compared to normal fetuses, intrauterine growth restricted fetuses show a difference in that the irregularity of the fetal heart is decreased. A more apparent difference is that the long-term fractal correlation of the fetal heart is increased and the fetal heart is smoother in the long-term scale.
确定胎儿生长受限胎儿的心率行为不规则性以及反映心率行为平滑度的短期和长期分形相关性是否发生变化。
研究了192例正常胎儿和86例妊娠31至42周的胎儿生长受限胎儿的胎心率数据。计算了用于量化不规则性的近似熵，以及用于量化短期（≤80次心跳，α1）和长期（>80次心跳，α2）分形标度指数的短期和长期分形相关性。
在胎儿生长受限胎儿中，近似熵显著降低（P<0.001）。α2值显著高于正常胎儿（P = 0.0001），在逐步判别分析中，α2在区分胎儿生长受限胎儿与正常胎儿方面比其他心率变异性指标表现更好（F = 34.2，P<0.0001）。
与正常胎儿相比，胎儿生长受限胎儿的不同之处在于胎儿心率的不规则性降低。更明显的差异是胎儿心脏的长期分形相关性增加，并且在长期尺度上胎儿心脏更平滑。
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