肌动蛋白动力学：肌动蛋白网络的组装与拆卸

Actin dynamics: assembly and disassembly of actin networks.

作者信息

Wear M A, Schafer D A, Cooper J A

机构信息

Department of Cell Biology and Physiology, Washington University, Box 8228, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.

出版信息

Curr Biol. 2000;10(24):R891-5. doi: 10.1016/s0960-9822(00)00845-9.

DOI:10.1016/s0960-9822(00)00845-9

PMID:11137023

Abstract

Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.

摘要

在迁移细胞的前沿组装分支状肌动蛋白丝网络需要WASp蛋白协同WASp激活剂Cdc42、磷脂酰肌醇-4,5-二磷酸（PIP(2)）和肌动蛋白结合蛋白对Arp2/3复合物进行刺激。随着肌动蛋白丝老化，网络的解体和去分支似乎与肌动蛋白结合的ATP水解有关。