Mlynarczyk S K, Panning B
University of California San Francisco, Department of Biochemistry and Biophysics, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143, USA.
Curr Biol. 2000;10(24):R899-903. doi: 10.1016/s0960-9822(00)00847-2.
A new study shows that expression of Tsix, an antisense Xist gene, can be controlled by imprinting, and that high Tsix activity during X inactivation can protect the future active X chromosome from silencing by Xist. Tsix and Xist seem to have a yin and yang relationship, with opposite effects on X inactivation.
一项新研究表明，反义Xist基因Tsix的表达可受印记调控，且在X染色体失活过程中高活性的Tsix能保护未来的活性X染色体不被Xist沉默。Tsix和Xist似乎存在阴阳关系，对X染色体失活有着相反的作用。
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