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通过在清醒自由活动大鼠中进行微透析测量，视交叉上核区域5-羟色胺（5-HT）1B自身受体活性的昼夜变化。

Circadian variation in the activity of the 5-HT(1B) autoreceptor in the region of the suprachiasmatic nucleus, measured by microdialysis in the conscious freely-moving rat.

作者信息

Garabette M L, Martin K F, Redfern P H

机构信息

Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY. B.T.G., 10 Fleet Place, London EC4 7SB.

出版信息

Br J Pharmacol. 2000 Dec;131(8):1569-76. doi: 10.1038/sj.bjp.0703753.

DOI:10.1038/sj.bjp.0703753

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1572511/

Abstract

Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine(1B) (5-HT(1B)) autoreceptor in the region of the suprachiasmatic nuclei (SCN) of freely moving conscious rats at six time points or zeitgeber times (ZTs) across the light:dark cycle. Infusion of the 5-HT(1A/1B) agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU24969) (1 microM) via the microdialysis probe produced a decrease in 5-HT output when applied at ZTs 3, 6, 15 and 21 (69.8+/-11.9, 59+/-11.7, 43.9+/-17.2 and 45.7+/-17.0% respectively). At ZTs 9 and 18 RU24969 (1 microm) failed to affect the 5-HT output significantly (28.0+/-11 and 32.8+/-24.6% decrease respectively). The profile of inhibition of 5-HT output following infusion of RU24969 (1 microM) at ZT 6 was unaffected by concurrent infusion of the specific 5-HT(1A) antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohe xanecarboxamide trihydrochloride (WAY100635) (1 microM) (52.48+/-17.5% decrease). The data demonstrate a circadian rhythm in the activity of the 5-HT(1B) autoreceptor in the region of the SCN.

摘要

采用脑内微透析技术，在自由活动的清醒大鼠的视交叉上核（SCN）区域，于光暗周期的六个时间点或授时因子时间（ZT），检测5-羟色胺（1B）（5-HT(1B)）终末自身受体的功能。通过微透析探针注入5-HT(1A/1B)激动剂5-甲氧基-3-(1,2,3,6-四氢-4-吡啶基)-1H-吲哚（RU24969）（1微摩尔），在ZT3、6、15和21时应用时，5-HT输出量减少（分别为69.8±11.9%、59±11.7%、43.9±17.2%和45.7±17.0%）。在ZT9和18时，RU24969（1微摩尔）未能显著影响5-HT输出量（分别减少28.0±11%和32.8±24.6%）。在ZT6时注入RU24969（1微摩尔）后对5-HT输出量的抑制情况，不受同时注入特异性5-HT(1A)拮抗剂N-[2-[4-(2-甲氧基苯基)-1-哌嗪基]乙基]-N-(2-吡啶基)环己烷甲酰胺三盐酸盐（WAY100635）（1微摩尔）的影响（减少52.48±17.5%）。数据表明，SCN区域5-HT(1B)自身受体的活性存在昼夜节律。