硝基咪唑与缺氧成像：三种含硝基咪唑基团的锝-99m配合物的合成：生物学结果
Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group: biological results.
作者信息
Riché F, d'Hardemare A D, Sèpe S, Riou L, Fagret D, Vidal M
机构信息
Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Université Joseph Fourier, UMR 5616-BP 53, Grenoble, France.
出版信息
Bioorg Med Chem Lett. 2001 Jan 8;11(1):71-4. doi: 10.1016/s0960-894x(00)00593-x.
Abstract
Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions.
摘要
合成了几种用硝基咪唑基团取代的锝-99m配合物，用于可视化缺氧组织。这些配合物在大鼠（离体心脏）上进行了测试，在缺氧条件下未显示出明显的摄取。
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