伴有克隆性嗜酸性粒细胞增多并伴有嗜酸性粒细胞性肺间质浸润的骨髓增生异常综合征。

Myelodysplastic syndrome with clonal eosinophilia accompanied by eosinophilic pulmonary interstitial infiltration.

作者信息

Kuroda J, Kimura S, Akaogi T, Hayashi H, Yamano T, Sasai Y, Horiike S, Taniwaki M, Abe T, Kobayashi Y, Kondo M

机构信息

Division of Hematology, Kyoto Second Red Cross Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Acta Haematol. 2000;104(2-3):119-23. doi: 10.1159/000039744.

DOI:10.1159/000039744

PMID:11154987

Abstract

We report a case of de novo myelodysplastic syndrome with clonal eosinophilia (MDS-Eo) and eosinophilic pulmonary interstitial infiltration, confirmed by autopsy. Cytogenetic study using Giemsa banding identified 47,XY,+1,der(1;7)(q10;p10),+8 in the marrow cells. Simple Giemsa staining revealed the same chromosomal aberration in metaphase spreads with eosinophilic granules, indicating the clonal proliferation of eosinophils. To our knowledge, our case is the 6th reported case of MDS-Eo with cytogenetically confirmed clonal eosinophilia, and the first autopsy of MDS-Eo. A review of the literature combined with our findings suggests that this type of chromosomal aberration might be involved in the as yet unknown pathogenesis of MDS-Eo.

摘要

我们报告一例经尸检确诊的新发伴克隆性嗜酸性粒细胞增多的骨髓增生异常综合征（MDS-Eo）及嗜酸性粒细胞性肺间质浸润病例。采用吉姆萨染色法的细胞遗传学研究在骨髓细胞中鉴定出47,XY,+1,der(1;7)(q10;p10),+8。简单吉姆萨染色显示中期分裂相中嗜酸性粒细胞颗粒存在相同的染色体畸变，表明嗜酸性粒细胞的克隆性增殖。据我们所知，我们的病例是第6例经细胞遗传学证实为克隆性嗜酸性粒细胞增多的MDS-Eo报告病例，也是首例MDS-Eo尸检病例。结合我们的研究结果对文献进行回顾表明，这种染色体畸变可能参与了MDS-Eo尚未明确的发病机制。