Christensen K L, Pedersen G P, Kristensen H G
Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Ø, Copenhagen, Denmark.
Int J Pharm. 2001 Jan 16;212(2):187-94. doi: 10.1016/s0378-5173(00)00596-2.
Development of stable dry emulsions being able to reform the original o/w-emulsion by reconstitution in water is presented. Dry emulsions were prepared by spray drying liquid o/w-emulsions in a laboratory spray dryer. Three hydroxypropylmethylcellulose (HPMC) types were applied as solid carrier and emulsifier. The lipid phase was fractionated coconut oil. The ratio of solid carrier to lipid phase influenced the reconstitution properties. It was possible to prepare redispersible dry emulsions of a lipid content up to 40% dry powder mass. The different HPMC types had no noticeable effect on the reconstitution properties, but too viscous liquid o/w-emulsions were difficult to atomise. The type of rotary atomizer, or the rate of rotation did not affect the technical properties of the dry emulsions containing 40% lipid. It was concluded that low viscosity HPMC was a useful solid carrier. The dry emulsions remained physically stable for at least 6 months.
本文介绍了一种能够通过在水中复溶来重新形成原始水包油乳液的稳定干乳液的开发。干乳液是通过在实验室喷雾干燥器中对液体水包油乳液进行喷雾干燥制备的。使用了三种羟丙基甲基纤维素(HPMC)类型作为固体载体和乳化剂。脂质相为分馏椰子油。固体载体与脂质相的比例影响复溶性能。可以制备脂质含量高达干粉质量40%的可再分散干乳液。不同类型的HPMC对复溶性能没有明显影响,但过于粘稠的液体水包油乳液难以雾化。旋转雾化器的类型或旋转速度对含40%脂质的干乳液的技术性能没有影响。得出的结论是,低粘度HPMC是一种有用的固体载体。干乳液在物理上至少稳定6个月。