Khan A A, Eid R A, Hamdi A
Department of Anatomy, College of Medicine & Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.
Pathology. 2000 Nov;32(4):253-7.
Many factors have been implicated in the aetiology of varicose veins; however, there is ample evidence implicating that the defect is in the wall of the lower limb veins. In order to know the pathological changes in the tunica intima of varicose veins, the smooth muscle cells (SMCs), collagen and elastin of varicose and control patients were studied by light and electron microscopy. The morphological changes in the SMCs, collagen and elastin point to a possible secretory or phagocytic role of the SMCs in producing abnormal immature collagen or elastin fibres or in modulation of function of SMCs due to excessive production of extracellular matrix (ECM).
许多因素与静脉曲张的病因有关;然而,有充分证据表明缺陷在于下肢静脉壁。为了了解静脉曲张内膜的病理变化,通过光镜和电镜研究了静脉曲张患者和对照患者的平滑肌细胞(SMC)、胶原蛋白和弹性蛋白。SMC、胶原蛋白和弹性蛋白的形态变化表明,SMC可能具有分泌或吞噬作用,可产生异常的未成熟胶原蛋白或弹性蛋白纤维,或由于细胞外基质(ECM)过度产生而调节SMC的功能。