Wijnberg I D, Back W, van der Kolk J H
Hoofdafdeling Gezondheidszorg Paard, Discipline Inwendige Ziekten, Universiteit Utrecht, Faculteit der Diergeneeskunde, Yalelaan 16, 3584 CM Utrecht.
Tijdschr Diergeneeskd. 2000 Dec 15;125(24):743-7.
This paper describes a case of unilateral stringhalt present for 18 months in the right hind limb of a 4-year-old Warmblood gelding. The only abnormalities detected by electromyography (EMG) were a prolonged insertion activity, fibrillation potentials, and positive waves at rest and enhanced EMG activity in the right lateral digital extensor muscle on muscle contraction. This was interpreted as denervation and hyperirritability of this muscle. Both similarities and differences with Australian stringhalt could be found. As described for horses suffering from Australian stringhalt, phenytoin sodium was administered orally in a dosage ranging from 15 to 9.3 mg/kg body weight in order to try to influence the hyperflexia. Therapeutic effects without side effects could be achieved at plasma concentrations between 5.1 and 9.9 mg/L at a dosage of 12 mg/kg body weight twice daily, which is consistent with data in the literature (5-10 mg/L). The EMG examination seems to help to clarify the aetiology of the classical form of stringhalt, since the only abnormality in this patient was an abnormal electrical activity in the lateral digital extensor muscle. As in Australian stringhalt, in this type of stringhalt phenytoin also relieved the hyperflexion of the tarsus.
本文描述了一例4岁温血 gelding 右后肢单侧间歇性跛行18个月的病例。肌电图(EMG)检测到的唯一异常是插入活动延长、纤颤电位和静息时的正波,以及右侧指外侧伸肌在肌肉收缩时肌电图活动增强。这被解释为该肌肉的去神经支配和兴奋性增高。可以发现与澳大利亚间歇性跛行既有相似之处也有不同之处。正如患有澳大利亚间歇性跛行的马匹一样,口服苯妥英钠,剂量为15至9.3毫克/千克体重,以试图影响过度屈曲。每日两次给予12毫克/千克体重的剂量,血浆浓度在5.1至9.9毫克/升之间时可取得无副作用的治疗效果,这与文献数据(5 - 10毫克/升)一致。肌电图检查似乎有助于阐明经典型间歇性跛行的病因,因为该患者唯一的异常是指外侧伸肌的异常电活动。与澳大利亚间歇性跛行一样,在这种类型的间歇性跛行中,苯妥英钠也缓解了跗关节的过度屈曲。