Fuster D, Frey F J, Ferrari P
Abteilung für Nephrologie und Hypertonie, Inselspital, Universität Bern.
Praxis (Bern 1994). 2000 Dec 7;89(49):2073-6.
This case report presents a patient who developed severe life-threatening hyperkalemia following combined treatment with an ACE-inhibitor and the aldosterone-antagonist spironolactone for his congestive heart failure and who also suffered from pre-existing moderate renal failure. The pathophysiological reasons and the clinical evidence for the treatment of congestive heart failure with a combination of ACE-inhibitors and aldosterone-antagonists are discussed in details. The reasons for the occurrence of hyperkalemia in this patient and how spironolactone should be prescribed in patients with congestive heart failure are also elucidated.
本病例报告介绍了一名患者,该患者因充血性心力衰竭接受血管紧张素转换酶抑制剂(ACE 抑制剂)和醛固酮拮抗剂螺内酯联合治疗后,出现了严重的、危及生命的高钾血症,且该患者先前已患有中度肾衰竭。文中详细讨论了使用 ACE 抑制剂和醛固酮拮抗剂联合治疗充血性心力衰竭的病理生理原因及临床证据。还阐明了该患者发生高钾血症的原因以及在充血性心力衰竭患者中应如何开具螺内酯的处方。