Shih I M, Kurman R J
Division of Gynecologic Pathology, Department of Pathology and Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Int J Gynecol Pathol. 2001 Jan;20(1):31-47. doi: 10.1097/00004347-200101000-00004.
An intermediate trophoblast is a distinctive trophoblastic cell population from which four trophoblastic lesions are thought to arise: exaggerated placental site (EPS), placental site nodule (PSN), placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). EPSs and PSTTs are related to the differentiation of the intermediate trophoblast in the implantation site (implantation site intermediate trophoblast), whereas PSNs and ETTs are related to the intermediate trophoblast of the chorion laeve (chorionic-type intermediate trophoblast). EPSs and PSNs are nonneoplastic lesions, whereas PSTTs and ETTs are neoplasms with a potential for local invasion and metastasis. Microscopically, intermediate trophoblastic lesions can be confused with a variety of trophoblastic and nontrophoblastic tumors, but an appreciation of the morphologic features and immunophenotype allows their diagnosis to be relatively straightforward in most instances. Correct diagnosis is important because each of these lesions may require different therapeutic approaches.
中间型滋养细胞是一种独特的滋养细胞群体，人们认为有四种滋养细胞病变起源于此：超常胎盘部位（EPS）、胎盘部位结节（PSN）、胎盘部位滋养细胞肿瘤（PSTT）和上皮样滋养细胞肿瘤（ETT）。EPS和PSTT与着床部位中间型滋养细胞（着床部位中间型滋养细胞）的分化有关，而PSN和ETT与平滑绒毛膜的中间型滋养细胞（绒毛膜型中间型滋养细胞）有关。EPS和PSN是非肿瘤性病变，而PSTT和ETT是具有局部侵袭和转移潜能的肿瘤。在显微镜下，中间型滋养细胞病变可能会与多种滋养细胞和非滋养细胞肿瘤混淆，但了解其形态学特征和免疫表型后，在大多数情况下其诊断相对简单。正确诊断很重要，因为这些病变中的每一种可能都需要不同的治疗方法。
