Frilling A, Görges R, Clauer U, Tecklenborg K, Broelsch C E
Klinik und Poliklinik für Allgemein- und Transplantationschirurgie, Universitätsklinikum Essen.
Chirurg. 2000 Dec;71(12):1474-9. doi: 10.1007/s001040051246.
The standard procedure in patients with primary hyperparathyroidism (pHPT) includes cervical exploration and identification of all four enlarged parathyroid glands. New localization techniques, i.e., ultrasonography associated with color duplex sonography, 99mTc-sestamibi scintigraphy and the possibility of intraoperative parathormone (iPTH) measurement permit minimally invasive parathyroidectomy (MIP). Three different methods have been established: minimally invasive open parathyroidectomy, endoscopic parathyroidectomy and video-assisted parathyroidectomy. We present our experience with open MIP with the patient under local anesthesia (LA).
In 25 patients with pHPT the operation was started under local anesthesia. Preoperatively, ultrasonography and sestamibi scintigraphy were performed in each patient. iPTH measurement was carried out intraoperatively.
In 23 patients (92%) the operation was done successfully in LA. There were no postoperative complications. During follow-up none of the patients developed hypercalcemia again.
MIP in connection with ultrasonography, sestamibi scintigraphy and intraoperative PTH measurement offers a promising treatment for patients with pHPT.
原发性甲状旁腺功能亢进症(pHPT)患者的标准治疗程序包括颈部探查和识别所有四个增大的甲状旁腺。新的定位技术,即超声检查联合彩色双功超声、99mTc-甲氧基异丁基异腈闪烁扫描以及术中甲状旁腺激素(iPTH)测量的可能性,使得微创甲状旁腺切除术(MIP)成为可能。已经确立了三种不同的方法:微创开放性甲状旁腺切除术、内镜甲状旁腺切除术和电视辅助甲状旁腺切除术。我们介绍在局部麻醉(LA)下对患者进行开放性MIP的经验。
对25例pHPT患者在局部麻醉下开始手术。术前,对每位患者进行超声检查和甲氧基异丁基异腈闪烁扫描。术中进行iPTH测量。
23例患者(92%)在局部麻醉下手术成功。无术后并发症。随访期间,无患者再次出现高钙血症。
MIP联合超声检查、甲氧基异丁基异腈闪烁扫描和术中PTH测量为pHPT患者提供了一种有前景的治疗方法。