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肝脏和小肠移植:治疗肝脏疾病和肠衰竭的治疗选择。

Liver and small bowel transplantation: therapeutic alternatives for the treatment of liver disease and intestinal failure.

作者信息

Gilroy R, Sudan D

机构信息

Division of Hepatology and Transplantation, University of Nebraska Medical Center, Omaka, USA.

出版信息

Semin Liver Dis. 2000;20(4):437-50. doi: 10.1055/s-2000-13151.

DOI:10.1055/s-2000-13151
PMID:11200414
Abstract

Intestinal transplantation is an established life-saving therapy for parenteral nutrition dependent patients suffering from severe complications of parenteral nutrition. Improvements in outcomes over the last decade have occurred with refinements in surgical technique, better immunosuppressive regimens, and clinical experience. The long-term results of intestinal transplantation are not well known and morbidity remains an important obstacle to wider application of this procedure to patients with short bowel syndrome (SBS). This article reviews the indications for intestinal transplantation, the evaluation of potential candidates, therapeutic considerations, postoperative management and common complications experienced by the recipients.

摘要

肠道移植是一种已确立的挽救生命的治疗方法,用于治疗依赖肠外营养且患有严重肠外营养并发症的患者。在过去十年中,随着手术技术的改进、更好的免疫抑制方案以及临床经验的积累,治疗效果有所改善。肠道移植的长期结果尚不清楚,发病率仍然是将该手术更广泛应用于短肠综合征(SBS)患者的一个重要障碍。本文综述了肠道移植的适应证、潜在候选者的评估、治疗考虑因素、术后管理以及受者常见的并发症。

相似文献

1
Liver and small bowel transplantation: therapeutic alternatives for the treatment of liver disease and intestinal failure.肝脏和小肠移植:治疗肝脏疾病和肠衰竭的治疗选择。
Semin Liver Dis. 2000;20(4):437-50. doi: 10.1055/s-2000-13151.
2
Short bowel syndrome and intestinal transplantation in children.儿童短肠综合征与肠道移植
Curr Opin Clin Nutr Metab Care. 2006 May;9(3):304-13. doi: 10.1097/01.mco.0000222116.68912.fc.
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Reversal of intestinal failure-associated liver disease in infants and children on parenteral nutrition: experience with 93 patients at a referral center for intestinal rehabilitation.肠衰竭相关肝病在肠外营养患儿中的逆转:肠康复转诊中心 93 例患儿的经验
J Pediatr Surg. 2010 Jan;45(1):84-7; discussion 87-8. doi: 10.1016/j.jpedsurg.2009.10.014.
4
Long-term outcomes of isolated liver transplantation for short bowel syndrome and intestinal failure-associated liver disease.孤立肝移植治疗短肠综合征和肠衰竭相关肝病的长期结果。
J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):547-51. doi: 10.1097/MPG.0b013e31823f42e7.
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Long-term parenteral nutrition in children who are potentially candidates for small bowel transplantation.对于可能适合小肠移植的儿童进行长期肠外营养。
Transplant Proc. 1994 Jun;26(3):1442.
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Current status of living donor small bowel transplantation.活体供者小肠移植的现状。
Curr Opin Organ Transplant. 2010 Jun;15(3):346-8. doi: 10.1097/MOT.0b013e3283398fa4.
7
[Small bowel transplantation].[小肠移植]
Cas Lek Cesk. 2005;144(7):438-40; discussion 441-4.
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[Small bowel transplantation as a treatment option for intestinal failure in children and adults].[小肠移植作为儿童和成人肠衰竭的一种治疗选择]
Ned Tijdschr Geneeskd. 2005 Feb 19;149(8):391-8.
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Clinical aspects of small-bowel transplantation.小肠移植的临床方面
Scand J Gastroenterol Suppl. 2000(232):65-8.
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Intestinal failure: A new era in clinical management.肠衰竭:临床管理的新时代。
J Gastroenterol Hepatol. 2009 Oct;24 Suppl 3:S86-92. doi: 10.1111/j.1440-1746.2009.06077.x.

引用本文的文献

1
Gastroenterology - Guidelines on Parenteral Nutrition, Chapter 15.胃肠病学 - 肠外营养指南,第15章。
Ger Med Sci. 2009 Nov 18;7:Doc13. doi: 10.3205/000072.
2
Isolated liver transplantation for treatment of liver failure secondary to intestinal failure.孤立性肝移植治疗肠衰竭继发肝衰竭。
Ital J Pediatr. 2009 Sep 15;35(1):28. doi: 10.1186/1824-7288-35-28.
3
The effect of intestinal plication on intestinal transit time in rats.肠折叠对大鼠肠道转运时间的影响。
Pediatr Surg Int. 2004 Jun;20(6):425-8. doi: 10.1007/s00383-004-1169-8. Epub 2004 May 13.
4
Influence of liver nonparenchymal cell infusion combined with cyclosporin A on rejection of rat small bowel transplantation.肝非实质细胞输注联合环孢素A对大鼠小肠移植排斥反应的影响
World J Gastroenterol. 2003 Dec;9(12):2859-62. doi: 10.3748/wjg.v9.i12.2859.
5
Combined small bowel and reduced auxiliary liver transplantation: case report.小肠联合减体积辅助肝移植:病例报告
World J Gastroenterol. 2002 Oct;8(5):956-60. doi: 10.3748/wjg.v8.i5.956.