Kharb S, Singh V, Ghalaut P S, Sharma A, Singh G P
J Assoc Physicians India. 2000 Oct;48(10):956-7.
To study lipid peroxidation, magnesium levels (Mg) in plasma and red cells (RBC), superoxide dismutase (SOD) and catalase (CAT) activities in the plasma and RBC of shock patients.
Twenty five patients with clinically defined septic shock and 30 healthy volunteers were selected for the study to study the parameters of oxidative stress.
Septic shock patients had higher activities of plasma and RBC SOD and CAT activities as compared to control. Also, plasma Mg and malonaldehyde (MDA) levels were higher in shock patients as compared to controls. While, RBC Mg levels were similar in two groups.
The finding of increased concentration of MDA, Mg, SOD and CAT in sepsis implicates oxygen free radicals in the pathophysiology and free radical scavengers may have a role in organ preservation.
研究休克患者血浆和红细胞中的脂质过氧化、镁水平（Mg）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性。
选取25例临床诊断为感染性休克的患者和30名健康志愿者进行研究，以研究氧化应激参数。
与对照组相比，感染性休克患者血浆和红细胞中的SOD和CAT活性更高。此外，与对照组相比，休克患者的血浆镁和丙二醛（MDA）水平更高。而两组的红细胞镁水平相似。
脓毒症中MDA、Mg、SOD和CAT浓度升高的发现表明氧自由基参与了病理生理过程，自由基清除剂可能在器官保护中发挥作用。
