E-钙黏蛋白、β-连环蛋白、P120连环蛋白在移行细胞膀胱癌患者中的预后价值。
Prognostic value of E-cadherin, beta-catenin, P120ctn in patients with transitional cell bladder cancer.
作者信息
Nakopoulou L, Zervas A, Gakiopoulou-Givalou H, Constantinides C, Doumanis G, Davaris P, Dimopoulos C
机构信息
Department of Pathology, Medical School, University of Athens, 75 Mikras Assias Str., Athens GR-115 27, Greece.
出版信息
Anticancer Res. 2000 Nov-Dec;20(6B):4571-8.
BACKGROUND
Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many human carcinomas.
MATERIALS AND METHODS
By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival.
RESULTS
Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07).
CONCLUSION
E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.
背景
已知E-钙黏蛋白-连环蛋白介导的黏附丧失在许多人类癌症的肿瘤进展中起主要作用。
材料与方法
通过免疫组织化学方法，我们研究了102例膀胱移行细胞癌（TCC）中E-钙黏蛋白、β-连环蛋白和p120连环蛋白的表达，并对这些表达与已知的临床病理参数及患者生存率进行了统计学分析。
结果
E-钙黏蛋白、β-连环蛋白和p120连环蛋白的异常表达与TCC的高分级和高分期相关（p < 0.001）。β-连环蛋白异常表达与患者生存率低具有统计学显著相关性（p = 0.03），而E-钙黏蛋白异常表达与肌层浸润性TCC患者的生存率低相关（p = 0.025）。然而，在多变量统计分析中，仅观察到E-钙黏蛋白与生存率低存在提示性关联（p = 0.06）。所有分子同时异常表达与患者生存率低存在提示性显著关联（p = 0.07）。
结论
E-钙黏蛋白表达可能是浸润性TCC患者有用的预后标志物。
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