单次口服依那普利后伊朗正常血压受试者体内血管紧张素转换酶（ACE）活性与平均血压之间的相关性

Correlation between ACE activity and mean blood pressure in Iranian normotensive subjects after oral administration of a single dose of enalapril.

作者信息

Ziai S A, Seyedhosseini D, Taiebi L, Salekmoghadam E, Mahmoudian M

机构信息

Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Acta Physiol Hung. 2000;87(2):153-9.

PMID:11205963

Abstract

Relationship between serum ACE activity and mean blood pressure (MAP) after administration of a single oral dose of the ACE inhibitor enalapril 10 and 20 mg tablets was investigated in 19 Iranian normotensive male subjects. Enalapril at doses, which maximally inhibit ACE activity, reduced MAP dose dependently. The t(max) of ACE inhibition decreased significantly by increasing the enalapril doses, but t(max) of MAP reduction did not change by increasing the dose. The AUC (area under the curve) of ACE inhibition versus time was significantly larger in 20 mg enalapril group compare to 10mg enalapril group (p<0.001). A significant correlation was found between log of residual ACE activity and MAP (r=0.4927; p<0.001). It is concluded that in Iranian normal subjects, after administration of a single oral dose of enalapril, MAP related to residual ACE activity.

摘要

在19名伊朗血压正常的男性受试者中，研究了单次口服10毫克和20毫克片剂的血管紧张素转换酶（ACE）抑制剂依那普利后，血清ACE活性与平均血压（MAP）之间的关系。依那普利在最大程度抑制ACE活性的剂量下，可使MAP呈剂量依赖性降低。随着依那普利剂量增加，ACE抑制的达峰时间（t(max)）显著缩短，但MAP降低的t(max)并未因剂量增加而改变。与10毫克依那普利组相比，20毫克依那普利组ACE抑制的曲线下面积（AUC）与时间的关系显著更大（p<0.001）。发现残余ACE活性的对数与MAP之间存在显著相关性（r=0.4927；p<0.001）。得出结论，在伊朗正常受试者中，单次口服依那普利后，MAP与残余ACE活性相关。