含8-酰胺基的假霉素B（PSB）类似物：新型抗真菌剂。
8-Amido-Bearing pseudomycin B (PSB) analogue: novel antifungal agents.
作者信息
Zhang Y Z, Sun X, Zeckner D J, Sachs R K, Current W L, Chen S H
机构信息
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lillly Corporate Center, Indianapolis, IN 46285, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jan 22;11(2):123-6. doi: 10.1016/s0960-894x(00)00606-5.
Abstract
During the course of a structure-activity relationship (SAR) study on novel depsinonapeptide pseudomycin B, we synthesized a total of 12 8-amidopseudomycin analogues via standard two-step sequence from either ZPSB 2 or AllocPSB 3. A number of these amides exhibited good in vitro antifungal activities.
摘要
在对新型去甲伪霉素B进行构效关系（SAR）研究的过程中，我们通过标准的两步序列从ZPSB 2或AllocPSB 3总共合成了12种8-氨基伪霉素类似物。其中一些酰胺表现出良好的体外抗真菌活性。
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