在C-7位带有碱性氨基吡啶的新型抗耐甲氧西林金黄色葡萄球菌头孢菌素。
New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position.
作者信息
Cho A, Glinka T W, Ludwikow M, Fan A T, Wang M, Hecker S J
机构信息
Microcide Pharmaceuticals, Inc., Mountain View, CA 94043, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jan 22;11(2):137-40. doi: 10.1016/s0960-894x(00)00603-x.
Abstract
Incorporation of a basic aminopyridine into the C-7 position of 3-(amine-substituted arylthio)-3-norcephalosporins, as in 3, afforded high potency against MRSA and acceptable solubility for intravenous administration.
摘要
将一种碱性氨基吡啶引入3-(胺基取代芳硫基)-3-去甲头孢菌素的C-7位，如化合物3所示，对耐甲氧西林金黄色葡萄球菌（MRSA）具有高效活性，且具有适合静脉给药的溶解度。
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