Huang K T, Sun C M
Department of Chemistry, National Dong Hwa University, Hualien, Taiwan.
Bioorg Med Chem Lett. 2001 Jan 22;11(2):271-3. doi: 10.1016/s0960-894x(00)00650-8.
An efficient and general liquid-phase method has been developed for the synthesis of a piperazine containing urea library. Reactions of the polymer bound carbamoyl chloride with primary or secondary amines afford ureas at ambient temperature. Desired compounds are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings.
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