一种糖基化聚阳离子DNA载体的合成与转染特性

Synthesis and transfecting properties of a glycosylated polycationic DNA vector.

作者信息

Jacopin C, Hofland H, Scherman D, Herscovici J

机构信息

LCBBMC UMR 7001 CNRS-ENSCP-Aventis-Gencell-Gencell, ENSCP, Paris, France.

出版信息

Bioorg Med Chem Lett. 2001 Feb 12;11(3):419-22. doi: 10.1016/s0960-894x(00)00683-1.

DOI:10.1016/s0960-894x(00)00683-1

PMID:11212125

Abstract

A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery.

摘要

合成了二烷基酰胺基甘氨酰羧基精胺的糖基化类似物。对11的物理化学性质和转染特性进行了评估，结果表明这种阳离子脂质在低电荷比下形成稳定颗粒，并且在基因传递方面效率较高。