药物基因组学的伦理和法律影响。

Ethical and legal implications of pharmacogenomics.

作者信息

Rothstein M A, Epps P G

机构信息

Institute for Bioethics, Health Policy and Law, University of Louisville School of Medicine, 101 West Chestnut, Louisville, Kentucky 40202, USA.

出版信息

Nat Rev Genet. 2001 Mar;2(3):228-31. doi: 10.1038/35056075.

DOI:10.1038/35056075

PMID:11256075

Abstract

Pharmacogenomics is the application of genomics technology to the discovery and development of drugs. A greater understanding of the way in which individuals with a particular genotype respond to a drug allows manufacturers to identify population subgroups that will benefit most from a particular drug. The increasing emphasis on pharmacogenomics is likely to raise ethical and legal questions regarding, among other things, the design of research studies, the construction of clinical trials and the pricing of drugs.

摘要

药物基因组学是将基因组技术应用于药物的发现与开发。对具有特定基因型的个体对药物的反应方式有更深入的了解，有助于制药商确定能从特定药物中获益最多的人群亚组。对药物基因组学日益增加的重视很可能引发一系列伦理和法律问题，其中包括研究设计、临床试验构建以及药物定价等方面。