Wolpert C, Jung W, Herwig S, Schimpf R, Lüderitz B
Medizinische Universitätsklinik und Poliklinik II Sigmund-Freud-Strasse 25 D-53105 Bonn, Germany.
Herz. 2001 Feb;26(1):55-63. doi: 10.1007/pl00002007.
The treatment of concomitant atrial tachyarrhythmias in patients with malignant ventricular tachyarrhythmias is a major challenge for new defibrillator devices. Atrial fibrillation is not only responsible for inappropriate ventricular therapies, but also reduced left ventricular performance, especially in patients with heart failure and severely depressed left ventricular function. Furthermore, it is a strong risk factor for the development of thromboembolism.
A new dual-chamber implantable defibrillator is capable of tiered atrial therapies for both regular and irregular atrial tachyarrhythmias. In first investigations a high sensitivity and specificity could be shown as well as a promising therapy efficacy of atrial antitachycardia ramp and burst pacing for the treatment of atrial tachycardias. Atrial ramp pacing has shown to be successful for regular atrial tachyarrhythmias in up to 60 to 70% of all episodes. The results have supported a programming of a high first shock energy for treatment of atrial fibrillation. The incidence of atrial fibrillation in patients with a history of atrial fibrillation or without is much higher in the present investigated patient populations than expected.
The more complicated and subtle new dual-chamber detection algorithm has proven to be safe and effective both for the detection of ventricular tachycardia but also in terms of an increase of specificity and a reduction of inappropriate ventricular therapies for atrial tachyarrhythmias.
对于恶性室性心律失常患者,同时合并房性快速心律失常的治疗是新型除颤器面临的一项重大挑战。心房颤动不仅会导致不适当的心室治疗,还会降低左心室功能,尤其是在心力衰竭和左心室功能严重受损的患者中。此外,它是血栓栓塞形成的一个重要危险因素。
一种新型双腔植入式除颤器能够对规则和不规则的房性快速心律失常进行分层心房治疗。在初步研究中,已显示出高敏感性和特异性,以及心房抗心动过速斜坡和猝发起搏治疗房性心动过速有良好的治疗效果。心房斜坡起搏已证明在高达60%至70%的所有发作中对规则房性快速心律失常有效。这些结果支持了设定高首次电击能量来治疗心房颤动。在目前研究的患者群体中,有房颤病史或无房颤病史患者的房颤发生率比预期高得多。
事实证明,更复杂、更精细的新型双腔检测算法对于室性心动过速的检测以及提高特异性和减少房性快速心律失常的不适当心室治疗而言都是安全有效的。