Wegener A, Laser H
Abteilung für Experimentelle Ophthalmologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn.
Klin Monbl Augenheilkd. 2001 Feb;218(2):67-77. doi: 10.1055/s-2001-12248.
Light scattering properties of the cornea and lens change in relation to age. This process is influenced by noxious factors which may induce the formation of cataracts. Four different camera types based on the Scheimpflug principle have been developed for documentation and evaluation of light scattering in the eye. Topcon SL-45. Zeiss SLC, Oxford CASE 2000, Nidek EAS 1000. Only the SL-45 and EAS 1000, however, have found a wider application in clinical and experimental studies.
Documentation of the eye with a Scheimpflug system is performed in a dark room after mydriasis induction. The rotating axis of the camera is aligned to the optical axis of the eye with fixation devices. Four meridians have been found appropriate for routine documentation. Image analysis is based on peak height and distance evaluation of 2 layers in the cornea and 10 layers in the lens. Standardization devices allow correction of technical differences in the recording process.
Evaluation of the ageing properties of the lens has evidenced typical density developments for each individual layer, the cortex increasing in density earlier than the nucleus. Cataract classification using a Scheimpflug camera provides an objective characterization of cataract type and progression. The outcome of surgical procedures changing the refractive power of the eye can be evaluated with a Scheimpflug camera as well. Its application in studies dealing with the ocular effects of Quinolones and HMG-CoA-reductase inhibitors, has demonstrated that Scheimpflug photography is the method of choice for establishment of a safety profile for a new drug.
Scheimpflug photography has proven to be ideal for objective documentation of the anterior eye segment in human and animal eyes, although both documentation and image analysis demand technical expertise to be reproducible.
角膜和晶状体的光散射特性随年龄变化。这一过程受可能诱发白内障形成的有害因素影响。基于谢姆弗勒原理已开发出四种不同类型的相机，用于记录和评估眼睛中的光散射。拓普康SL - 45、蔡司SLC、牛津CASE 2000、尼德克EAS 1000。然而，只有SL - 45和EAS 1000在临床和实验研究中得到了更广泛的应用。
在散瞳后于暗室中使用谢姆弗勒系统对眼睛进行记录。通过固定装置将相机的旋转轴与眼睛的光轴对齐。已发现四条子午线适用于常规记录。图像分析基于对角膜中的2层和晶状体中的10层的峰值高度和距离评估。标准化装置可校正记录过程中的技术差异。
对晶状体老化特性的评估已证明各层具有典型的密度变化，皮质密度比核密度更早增加。使用谢姆弗勒相机进行白内障分类可提供白内障类型和进展的客观特征。改变眼睛屈光力的手术程序的结果也可用谢姆弗勒相机进行评估。其在涉及喹诺酮类和HMG - CoA还原酶抑制剂眼部效应的研究中的应用表明，谢姆弗勒摄影是建立新药安全性概况的首选方法。
尽管记录和图像分析都需要专业技术才能实现可重复性，但谢姆弗勒摄影已被证明是客观记录人眼和动物眼前节的理想方法。
