17β-雌二醇对先兆子痫妇女离体网膜动脉的影响。
The effect of 17beta-estradiol on isolated omental arteries from preeclamptic women.
作者信息
Vedernikov Y P, Saade G R, Belfort M A, Wen T S, Garfield R E
机构信息
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):46-51. doi: 10.1016/s0301-2115(00)00359-6.
OBJECTIVE
To study the effect of 17beta-estradiol on isolated omental arteries from preeclamptic women.
STUDY DESIGN
Rings of omental artery with intact endothelium were mounted in organ chambers for isometric tension recording. We studied the effect of pharmacological concentrations of 17beta-estradiol on potassium chloride-induced tension and the concentration-contraction relationships for norepinephrine and calcium.
RESULTS
Cumulative application of 17beta-estradiol, in a concentration-dependent manner, relaxed potassium chloride contracted rings. Sixty minutes of incubation with 17beta-estradiol (10(-5)mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium. Tamoxifen (10(-6)mol/l) did not antagonize the inhibitory actions of 17beta-estradiol.
CONCLUSIONS
Pharmacological concentrations of 17beta-estradiol retain the capability for relaxing omental artery rings from preeclamptic women. The loss of refractoriness to norepinephrine, increased responsiveness to calcium ions and decreased ability of 17beta-estradiol to inhibit calcium-induced tension may be responsible for increased vascular reactivity in preeclampsia.
目的
研究17β-雌二醇对先兆子痫患者离体网膜动脉的作用。
研究设计
将具有完整内皮的网膜动脉环安装在器官浴槽中进行等长张力记录。我们研究了药理浓度的17β-雌二醇对氯化钾诱导的张力以及去甲肾上腺素和钙的浓度-收缩关系的影响。
结果
累积应用17β-雌二醇以浓度依赖性方式使氯化钾收缩的动脉环舒张。用17β-雌二醇（10⁻⁵mol/L）孵育60分钟可减弱对氯化钾、去甲肾上腺素和钙产生的张力。他莫昔芬（10⁻⁶mol/L）不能拮抗17β-雌二醇的抑制作用。
结论
药理浓度的17β-雌二醇保留了舒张先兆子痫患者网膜动脉环的能力。对去甲肾上腺素不应性的丧失、对钙离子反应性的增加以及17β-雌二醇抑制钙诱导张力能力的降低可能是先兆子痫中血管反应性增加的原因。
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