术前血小板增多是Ⅲ期和Ⅳ期子宫内膜癌的独立预后因素。

Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.

作者信息

Scholz H S, Petru E, Gücer F, Haas J, Tamussino K, Winter R

机构信息

Department of Obstetrics and Gynecology, University of Graz, Auenbruggerplatz 14, Graz, A-8036, Austria.

出版信息

Anticancer Res. 2000 Sep-Oct;20(5C):3983-5.

PMID:11268488

Abstract

BACKGROUND

To identify prognostic factors in stage III and IV endometrial cancer with special attention to pretreatment platelet count.

MATERIALS AND METHODS

59 patients with FIGO stage III or IV disease operated on between 1983 and 1993 were analyzed. Patients with preoperative thrombocytosis were compared with those without thrombocytosis. Prognostic factors were analyzed with a Cox proportional hazard model.

RESULTS

With the exception of age, there were no significant differences between patients with or without thrombocytosis. At multivariate analysis, five-year disease-free survival was influenced significantly by FIGO stage (stage III vs stage IV; p = 0.009), thrombocytosis (p = 0.02) and cervical involvement (p = 0.024). Similarly, overall five-year survival was significantly influenced by stage (p < 0.001), cervical involvement (p = 0.005) and thrombocytosis (p = 0.01). Age, histology, grade, myometrial invasion, lymph-vascular space involvement or spread to adnexae were not significantly associated with survival.

CONCLUSION

Thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.

摘要

背景

确定Ⅲ期和Ⅳ期子宫内膜癌的预后因素，特别关注治疗前血小板计数。

材料与方法

分析了1983年至1993年间接受手术治疗的59例FIGOⅢ期或Ⅳ期疾病患者。将术前血小板增多症患者与无血小板增多症患者进行比较。采用Cox比例风险模型分析预后因素。

结果

除年龄外，有或无血小板增多症的患者之间无显著差异。多因素分析显示，FIGO分期（Ⅲ期与Ⅳ期；p = 0.009）、血小板增多症（p = 0.02）和宫颈受累（p = 0.024）对五年无病生存率有显著影响。同样，总体五年生存率受分期（p < 0.001）、宫颈受累（p = 0.005）和血小板增多症（p = 0.01）的显著影响。年龄、组织学类型、分级、肌层浸润、淋巴血管间隙受累或附件转移与生存率无显著相关性。