81m氪通气闪烁扫描术证实奥扎格雷与普仑司特联合治疗运动诱发性哮喘的疗效——病例报告
Beneficial effect of combination therapy with ozagrel and pranlukast in exercise-induced asthma demonstrated by krypton-81 m ventilation scintigraphy--a case report.
作者信息
Takahashi N, Ishibashi Y, Murakami Y, Shimizu H, Ohta Y, Asanuma T, Katoh H, Sano K, Shimada T
机构信息
4th Department of Internal Medicine, Shimane Medical University, Izumo City, Shimane, Japan.
出版信息
Ann Acad Med Singap. 2000 Nov;29(6):766-9.
INTRODUCTION
We evaluated the effect of combination therapy with thromboxane A2 synthesis inhibitor and leukotriene receptor antagonist in a patient with exercise-induced asthma using krypton-81 m ventilation scintigraphy.
CLINICAL PICTURE
In a patient with exercise-induced asthma, we found exercise-induced abnormalities of respiratory function test and ventilation scintigraphy, and increases in plasma concentrations of thromboxane B2 and leukotriene C4 with exercise.
TREATMENT
A thromboxane A2 synthesis inhibitor (ozagrel) and a leukotriene receptor antagonist (pranlukast) were prescribed.
OUTCOME
After treatment for 2 weeks, abnormalities of respiratory function test and ventilation scintigraphy improved.
CONCLUSIONS
The combination therapy with ozagrel and pranlukast might be useful for the relief of symptoms in patients with exercise-induced asthma, and krypton-81 m ventilation scintigraphy could be a useful tool for visible evaluation of treatment.
引言
我们使用氪-81m通气闪烁扫描评估了血栓素A2合成抑制剂与白三烯受体拮抗剂联合治疗对一名运动诱发性哮喘患者的效果。
临床情况
在一名运动诱发性哮喘患者中，我们发现运动诱发的呼吸功能测试和通气闪烁扫描异常，以及运动时血浆血栓素B2和白三烯C4浓度升高。
治疗
开具了一种血栓素A2合成抑制剂（奥扎格雷）和一种白三烯受体拮抗剂（普仑司特）。
结果
治疗2周后，呼吸功能测试和通气闪烁扫描的异常情况有所改善。
结论
奥扎格雷和普仑司特联合治疗可能有助于缓解运动诱发性哮喘患者的症状，氪-81m通气闪烁扫描可能是评估治疗效果的有用工具。
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