Skowroń J, Miranowicz-Dzierzawska K, Zapór L, Gołofit-Szymczak M, Starek A
Central Institute for Labour Protection, Department of Chemical and Aerosol Hazards, Czerniakowska 16, 00-701 Warsaw, Poland.
Int J Occup Saf Ergon. 2001;7(1):35-47. doi: 10.1080/10803548.2001.11076475.
Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethylene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.
研究了在大鼠中反复给予中等剂量水平时某些有机溶剂的代谢和毒代动力学相互作用。结果表明，正己烷和乙苯在2周期间均显著抑制四氯乙烯的代谢。正己烷和四氯乙烯增强了乙苯的代谢，而乙苯仅在实验结束时抑制正己烷的代谢。与单独给予这些化学物质后观察到的情况相比，用有机溶剂混合物处理的大鼠组织中的生化变化，尤其是非蛋白质巯基水平的下降，明显不那么显著。这些结果表明，烃类和氯代烯烃之间的代谢相互作用可能导致对这些化合物的生物学反应发生改变。
