Herfarth K K, Gutwein S, Debus J
Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.
Semin Surg Oncol. 2001 Jan-Feb;20(1):13-23. doi: 10.1002/ssu.1012.
Astrocytomas account for the majority of primary brain tumors. Low-grade tumors are slowly growing tumors with relatively long overall survival. However, a high percentage of these tumors transform to more malignant, high-grade tumors. High-grade gliomas (anaplastic astrocytomas and glioblastoma multiforme) have a poor prognosis. Treatment options are capable of prolonging the natural history of the disease, but the long-term survival is poor. This review discusses the different postoperative treatment options and the prognostic factors in low- and high-grade astrocytomas.
星形细胞瘤占原发性脑肿瘤的大多数。低级别肿瘤生长缓慢,总体生存期相对较长。然而,这些肿瘤中有很大比例会转变为更具恶性的高级别肿瘤。高级别胶质瘤(间变性星形细胞瘤和多形性胶质母细胞瘤)预后较差。治疗方案能够延长疾病的自然病程,但长期生存率较低。本综述讨论了低级别和高级别星形细胞瘤不同的术后治疗方案及预后因素。