Ackerman N B
Surg Gynecol Obstet. 1975 Jun;140(6):885-8.
The effect of cooling, freezing and warming temperatures on the flow of lymph from the intestines was studied in dogs. When intestinal temperatures were dropped to an average of approximately 40 degrees F., an immediate decrease in lymph flow occurred to a mean value 33 per cent of control levels. With rewarming, lymph flow increased rapidly, rebounding to a level almost twice as great as that in controls. When the intestines were subjected to hypothermia to the point of freezing, lymph flow decreased immediately with flow rates dropping to only 6.6 per cent of control levels. Techniques for achieving freezing in these studies were inefficient, and uniform freezing was not always obtained. Again, with rewarming there was an immediate rise in lymph flow to levels significantly above those in controls. In hyperthermic studies to temperatures of 103 degrees F., a biphasic reaction was noted with an initial increase in lymph flow averaging 71 per cent higher than that in controls followed rapidly by a drop in lymph flow significantly below control levels. These experiments demonstrate that hypothermia, particularly below freezing temperatures, may rapidly decrease and virtually stop lymph flow from an intestinal segment. This suggests that hypothermia might be useful as an adjunctive measure in the operative management of patients with carcinomas of the gastrointestinal tract.
研究了降温、冷冻和升温对犬肠道淋巴液流动的影响。当肠道温度降至平均约40华氏度时，淋巴液流动立即减少，平均值降至对照水平的33%。随着复温，淋巴液流动迅速增加，反弹至几乎是对照水平两倍的程度。当肠道遭受低温直至冷冻时，淋巴液流动立即减少，流速降至仅为对照水平的6.6%。在这些研究中实现冷冻的技术效率不高，且并非总能实现均匀冷冻。同样，随着复温，淋巴液流动立即上升至明显高于对照水平。在体温升至103华氏度的高温研究中，观察到双相反应，淋巴液流动最初平均比对照水平高出71%，随后迅速降至明显低于对照水平。这些实验表明，低温，尤其是低于冷冻温度时，可能会迅速减少并几乎停止肠道段的淋巴液流动。这表明低温可能作为胃肠道癌患者手术治疗的辅助措施有用。
