Lee A J, Evans C J, Hau C M, Fowkes F G
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, Teviot Place, EH8 9AG, Edinburgh, UK.
J Clin Epidemiol. 2001 Apr;54(4):423-9. doi: 10.1016/s0895-4356(00)00300-0.
The purpose of the present study was to determine the relationship between fiber intake, constipation, and clinical venous disease in the general population. The Edinburgh Vein Study was comprised of 1566 men and women aged 18-64 years who were selected at random from the age-sex registers of 12 general practices. Fiber intake, intestinal transit time, defecation frequency and the prevalence of straining at stool were all found to be significantly different between the sexes. Men who reported that they strained to start passing a motion showed a higher prevalence of mild and severe trunk varices compared to men who did not strain. After adjustment for social class, BMI and mobility at work, this group of men showed a significantly elevated risk of having severe trunk varices (OR 2.76, 95% CI 1.16, 6.58). In contrast, no consistent relationships were seen among women. Overall, within this Western general population, an association between dietary fiber, constipation and the presence or severity of varicose veins was not supported.
本研究的目的是确定普通人群中纤维摄入量、便秘与临床静脉疾病之间的关系。爱丁堡静脉研究纳入了1566名年龄在18 - 64岁之间的男性和女性，他们是从12家普通诊所的年龄 - 性别登记册中随机选取的。研究发现，纤维摄入量、肠道运输时间、排便频率以及用力排便的发生率在男女之间均存在显著差异。与没有用力排便的男性相比，报告称开始排便时用力的男性轻度和重度躯干静脉曲张的患病率更高。在对社会阶层、体重指数和工作活动能力进行调整后，这组男性出现严重躯干静脉曲张的风险显著升高（比值比2.76，95%置信区间1.16，6.58）。相比之下，在女性中未发现一致的关系。总体而言，在这个西方普通人群中，膳食纤维、便秘与静脉曲张的存在或严重程度之间不存在关联。
