Malakoff A F, Schmidt J D
Urology. 1975 Apr;5(4):510-3. doi: 10.1016/0090-4295(75)90077-1.
A fifty-three-year-old man with epidermoid carcinoma of the penis metastatic to the right inguinal lymph nodes and adjacent areas was found to have persistent hypercalcemia. Associated with this biochemical abnormality was an elevated parathormone activity in the absence of any bony metastases. Other than a transient response to furosemide-inducded diuresis he was refractory to treatment with oral inorganic phosphates and mithramycin. Ablation of the primary tumor did not affect his hypercalcemia. However, when therapy using external irradiation and parenteral bleomycin was directed to the metastases, his serum calcium stabilized and became normal and remained so until further progression of his humor. We postulate that the penile cancer metastases were elaborating parathyroid hormone-like substances responsible for the hypercalcemia and suppression of normal parathyroid activity.
一名53岁男性，阴茎表皮样癌已转移至右侧腹股沟淋巴结及邻近区域，发现其存在持续性高钙血症。在无任何骨转移的情况下，与这种生化异常相关的是甲状旁腺激素活性升高。除了对速尿诱导的利尿有短暂反应外，他对口服无机磷酸盐和光辉霉素治疗无效。原发肿瘤切除并未影响其高钙血症。然而，当使用外照射和静脉注射博来霉素对转移灶进行治疗时，他的血清钙稳定并恢复正常，直至病情进一步进展前一直保持正常。我们推测阴茎癌转移灶分泌了甲状旁腺激素样物质，导致了高钙血症并抑制了正常甲状旁腺的活性。
