载脂蛋白H在2型糖尿病合并微量白蛋白尿患者中升高。

Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria.

作者信息

Cavallo Perin P, Gruden G, Giunti S, Arnaldi L, Cassader M, Gambino R, Pagano G

机构信息

Department of Internal Medicine, University of Turin, Turin, Italy.

出版信息

Nutr Metab Cardiovasc Dis. 2000 Dec;10(6):311-4.

PMID:11302005

Abstract

BACKGROUND AND AIM

Serum apolipoprotein H (Apo H) levels are increased in hyperlipidemic subjects and type 2 diabetics, but unknown in microalbuminuria, another disorder with an increased cardiovascular risk. We looked to see whether increased Apo H levels are associated with microalbuminuria in type 2 diabetes.

METHODS AND RESULTS

Serum Apo H was calculated in 20 normoalbuminuric and 17 microalbuminuric type 2 diabetics matched for age, sex, body mass index (BMI), glycosylated haemoglobin, plasma lipids and duration of diabetes, and also compared with 20 non-diabetic controls matched for age, sex, BMI and plasma lipids. Mean serum Apo H was significantly higher in the microalbuminuric patients (31.12 +/- 1.58 SEM vs 25.25 +/- 1.52 and 24.72 +/- 0.99 mg/dL, p = 0.003).

CONCLUSION

Serum apo H levels are increased in type 2 diabetics with microalbuminuria.

摘要

背景与目的

高脂血症患者和2型糖尿病患者血清载脂蛋白H（Apo H）水平升高，但在微量白蛋白尿（另一种心血管风险增加的疾病）患者中情况未知。我们旨在研究2型糖尿病患者Apo H水平升高是否与微量白蛋白尿相关。

方法与结果

计算了20例年龄、性别、体重指数（BMI）、糖化血红蛋白、血脂及糖尿病病程相匹配的正常白蛋白尿2型糖尿病患者和17例微量白蛋白尿2型糖尿病患者的血清Apo H水平，并与20例年龄、性别、BMI和血脂相匹配的非糖尿病对照者进行比较。微量白蛋白尿患者的平均血清Apo H水平显著更高（分别为31.12±1.58 SEM、25.25±1.52和24.72±0.99 mg/dL，p = 0.003）。