双相情感障碍和分裂情感性障碍中的非典型抗精神病药物。

Atypical antipsychotics in bipolar and schizoaffective disorders.

作者信息

Brown E S, Thomas N R, Carmody T, Mahadi S, Nejtek V A

机构信息

University of Texas Southwestern Medical Center at Dallas Department of Psychiatry, 75390-9070, USA.

出版信息

Pharmacopsychiatry. 2001 Mar;34(2):80-1. doi: 10.1055/s-2001-15179.

DOI:10.1055/s-2001-15179

PMID:11302568

Abstract

No data are available comparing the relative efficacy of different atypical agents in patients with bipolar disorder. A chart review of bipolar and schizoaffective disorder patients who had received courses of at least two atypical agents (n = 33) in a community psychiatry system was conducted. No differences in rates of hospitalizations were found between individual atypical agents or between atypical agents as a class and conventional neuroleptics. However, a significant reduction in rates of emergency room visits was found with atypical agents compared to conventional neuroleptics, with a trend toward greater reduction with clozapine compared to other atypical antipsychotics. Larger prospective studies are needed to confirm these preliminary observations.

摘要

目前尚无数据比较不同非典型药物在双相情感障碍患者中的相对疗效。对社区精神病学系统中接受过至少两种非典型药物疗程治疗的双相情感障碍和精神分裂症患者进行了图表回顾（n = 33）。在个体非典型药物之间，或作为一个类别与传统抗精神病药物之间，未发现住院率有差异。然而，与传统抗精神病药物相比，非典型药物显著降低了急诊就诊率，与其他非典型抗精神病药物相比，氯氮平有更大幅度降低的趋势。需要开展更大规模的前瞻性研究来证实这些初步观察结果。