采用基于抗体的免疫吸附法成功治疗意义未明的IgM型丙种球蛋白病相关的多发性神经病。

Successful management of polyneuropathy associated with IgM gammopathy of undetermined significance with antibody-based immunoadsorption.

作者信息

Toepfer M, Schroeder M, Müller-Felber W, Lochmüller H, Sitter T, Pongratz D, Schiffl H

机构信息

Division of Nephrology, Medizinische Klinik, Ludwig-Maximilians-Universität, München, Germany.

出版信息

Clin Nephrol. 2000 May;53(5):404-7.

PMID:11305816

Abstract

Peripheral polyneuropathies associated with monoclonal IgM gammopathy of undetermined significance often have a progressive course and optimal treatment has not been established. We report on a patient diagnosed with polyneuropathy associated with benign IgM gammopathy, who was successfully treated with antibody-based immunoadsorption only. The neurological symptoms of the patient improved continuously over six months of treatment. Controlled trials should be performed to define this indication for antibody-based immunoadsorption therapy.

摘要

意义未明的单克隆IgM丙种球蛋白病相关的周围性多发性神经病通常呈进行性病程，尚未确立最佳治疗方法。我们报告了一例诊断为良性IgM丙种球蛋白病相关多发性神经病的患者，该患者仅通过基于抗体的免疫吸附治疗就获得了成功。患者的神经症状在治疗的六个月中持续改善。应进行对照试验以明确基于抗体的免疫吸附疗法的这一适应证。