Lozman J, Dutton R E, English M, Powers S R
Ann Surg. 1975 Mar;181(3):317-24. doi: 10.1097/00000658-197503000-00013.
Pharmacologic doses of methylprednisolone sodium succinate were administered to 10 critically ill patients when the steroid was the only variable. Measurements of respiratory and circulatory physiologic parameters were obtained in all patients prior to injection and at 30 and 90 minutes following injection of methylprednisolone sodium succinate. A significant increase in Cardiac Index was seen (P less than .01) which appeared to be in association with a decrease in pulmonary vascular resistance (P less than .01) at a time when physiologic shunting of blood through the lungs increased (P less than .01). These changes imply improved perfusion of non- or poorly ventilated portions of the lungs. Four of ten patients demonstrated removal of lactate by the lung during the control period. Following methylprednisolone sodium succinate injection, 9 of 10 patients demonstrated production or a washout of lactate from the lungs.
当类固醇是唯一变量时，对10名重症患者给予药理剂量的琥珀酸钠甲泼尼龙。在注射琥珀酸钠甲泼尼龙之前以及注射后30分钟和90分钟，对所有患者进行呼吸和循环生理参数测量。观察到心脏指数显著增加（P小于0.01），这似乎与肺血管阻力降低（P小于0.01）相关，而此时通过肺的生理性血液分流增加（P小于0.01）。这些变化意味着肺的未通气或通气不良部分的灌注得到改善。10名患者中有4名在对照期显示肺清除乳酸。注射琥珀酸钠甲泼尼龙后，10名患者中有9名显示肺产生或清除乳酸。
