复发性自然流产患者血液中封闭抗体与妊娠结局及静脉注射免疫球蛋白治疗的关系
Blocking antibodies in blood from patients with recurrent spontaneous abortion in relation to pregnancy outcome and intravenous immunoglobulin treatment.
作者信息
Jablonowska B, Palfi M, Ernerudh J, Kjellberg S, Selbing A
机构信息
Division of Obstetrics and Gynecology, University Hospital, Linköping, Sweden.
出版信息
Am J Reprod Immunol. 2001 Apr;45(4):226-31. doi: 10.1111/j.8755-8920.2001.450405.x.
PROBLEM
To study whether the occurrence of mixed lymphocyte culture (MLC) blocking antibodies is associated with pregnancy outcome in women with unexplained recurrent spontaneous abortion (RSA) and the in vivo effect of intravenous immunoglobulin (IVIG) treatment on MLC blocking effect.
METHOD OF STUDY
Blood samples from 41 RSA patients were obtained before and after pregnancy, and blocking antibodies were estimated by one-way MLC assay. The patients received IVIG or placebo (saline) during pregnancy. Additionally, prepregnancy blood samples from 31 RSA women and 10 controls were obtained.
RESULTS
We found no correlation between blocking antibodies before pregnancy and the pregnancy outcome. The occurrence of blocking antibodies was not affected by pregnancy or IVIG treatment.
CONCLUSIONS
Blocking antibodies have no predictive value for the pregnancy outcome in RSA patients, and their production seems not to be affected by IVIG.
问题
研究混合淋巴细胞培养（MLC）封闭抗体的出现是否与不明原因复发性自然流产（RSA）女性的妊娠结局相关，以及静脉注射免疫球蛋白（IVIG）治疗对MLC封闭效应的体内影响。
研究方法
收集41例RSA患者妊娠前后的血样，采用单向MLC试验评估封闭抗体。患者在妊娠期间接受IVIG或安慰剂（生理盐水）治疗。此外，还收集了31例RSA女性和10例对照的孕前血样。
结果
我们发现妊娠前封闭抗体与妊娠结局之间无相关性。妊娠或IVIG治疗对封闭抗体的出现无影响。
结论
封闭抗体对RSA患者的妊娠结局无预测价值，其产生似乎不受IVIG影响。
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