Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci P G, Ballabio A
Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy.
EMBO J. 2001 May 1;20(9):2140-51. doi: 10.1093/emboj/20.9.2140.
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
一种基于系统数据收集的功能基因组学方法被用于表征一个包含三重基序(TRIM)的蛋白质家族。总共研究了37个TRIM基因/蛋白质,其中21个是新发现的。结果表明,TRIM蛋白具有共同的功能:通过同型多聚化,它们识别特定的细胞区室。