Valat J P, Accardo S, Reginster J Y, Wouters M, Hettich M, Lieu P L
CHU Trousseau, Service de Rhumatologie, Tours, France.
Inflamm Res. 2001 Mar;50 Suppl 1:S30-4. doi: 10.1007/PL00000218.
The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine.
229 patients with radiologically confirmed osteoarthritis of the lumbar spine.
Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment.
The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049).
Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated.
本研究旨在评估美洛昔康与双氯芬酸相比，对腰椎骨关节炎患者的疗效和耐受性。
229例经放射学确诊的腰椎骨关节炎患者。
每日一次服用美洛昔康7.5毫克片剂或双氯芬酸100毫克缓释片。在基线以及治疗3天、7天和14天后评估疗效和耐受性参数。
两种药物具有同等的短期疗效，在第3天时腰椎活动疼痛显著减轻（p<0.05）。次要疗效变量在第3天、7天和14天也有显著改善。两种药物之间无统计学显著差异，不过根据研究者评估（p = 0.0072）以及患者评估（p = 0.049），美洛昔康的总体耐受性显著优于双氯芬酸。
美洛昔康和双氯芬酸在缓解腰椎骨关节炎相关急性疼痛方面等效。然而，美洛昔康的耐受性要好得多。
Zotero 插件