具有缺失gE表位的水痘-带状疱疹病毒：人类抗体反应产生免疫压力的证据
Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response.
作者信息
Padilla J A, Grose C
机构信息
Department of Microbiology & Pediatrics, University of Iowa, Iowa City, USA.
出版信息
Arch Virol Suppl. 2001(17):27-39. doi: 10.1007/978-3-7091-6259-0_4.
PMID:11339548
Abstract
The varicella-zoster virus (VZV) genome contains about 70 open reading frames (ORF). ORF 68 codes for glycoprotein gE, formerly called gpl, which is the predominant VZV glycoprotein; gE is a typical type 1 transmembrane protein with 623 amino acids. Recently, a variant virus was discovered which has a mutation in gE codon 150; this mutation converts an aspartic acid into an asparagine residue.
摘要
水痘带状疱疹病毒（VZV）基因组包含约70个开放阅读框（ORF）。ORF 68编码糖蛋白gE，以前称为gpl，它是主要的VZV糖蛋白；gE是一种典型的1型跨膜蛋白，有623个氨基酸。最近，发现了一种变异病毒，其gE密码子150发生了突变；这种突变将一个天冬氨酸残基转变为一个天冬酰胺残基。
相似文献
1
Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response.
Arch Virol Suppl. 2001(17):27-39. doi: 10.1007/978-3-7091-6259-0_4.
2
Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus.
Virology. 1995 Dec 20;214(2):531-40. doi: 10.1006/viro.1995.0064.
3
Stability of a varicella-zoster virus glycoprotein E epitope.
Arch Virol. 2000;145(1):85-97. doi: 10.1007/s007050050007.
4
A systematic approach for the identification of novel, serologically reactive recombinant Varicella-Zoster Virus (VZV) antigens.
Virol J. 2010 Jul 20;7:165. doi: 10.1186/1743-422X-7-165.
5
Antigenic variation of varicella zoster virus Fc receptor gE: loss of a major B cell epitope in the ectodomain.
Virology. 1998 Sep 15;249(1):21-31. doi: 10.1006/viro.1998.9313.
6
Immunohistochemical identification of varicella-zoster virus gene 63-encoded protein (IE63) and late (gE) protein on smears and cutaneous biopsies: implications for diagnostic use.
J Med Virol. 1995 Dec;47(4):342-7. doi: 10.1002/jmv.1890470409.
7
Induction of neutralizing antibody and T-cell responses to varicella-zoster virus (VZV) using Ty-virus-like particles carrying fragments of glycoprotein E (gE).
Vaccine. 1997 Apr-May;15(6-7):709-19. doi: 10.1016/s0264-410x(96)00228-9.
8
Varicella-zoster virus glycoprotein gpI/gpIV receptor: expression, complex formation, and antigenicity within the vaccinia virus-T7 RNA polymerase transfection system.
J Virol. 1993 Jan;67(1):305-14. doi: 10.1128/JVI.67.1.305-314.1993.
9
Neutralizing antibody responses induced by varicella-zoster virus gE and gB glycoproteins following infection, reactivation or immunization.
J Med Virol. 1997 Sep;53(1):63-8. doi: 10.1002/(sici)1096-9071(199709)53:1<63::aid-jmv11>3.0.co;2-y.
10
Nucleotide sequence analysis of varicella-zoster virus glycoprotein E epitope coding regions.
Vaccine. 2001 Jul 16;19(28-29):3830-3. doi: 10.1016/s0264-410x(01)00147-5.
引用本文的文献
1
Complete DNA sequence analyses of the first two varicella-zoster virus glycoprotein E (D150N) mutant viruses found in North America: evolution of genotypes with an accelerated cell spread phenotype.
J Virol. 2004 Jul;78(13):6799-807. doi: 10.1128/JVI.78.13.6799-6807.2004.
Zotero 插件