Clark D I, Ahmed A B, Baxendale B R, Moran C G
Queen's Medical Centre, Nottingham, England.
J Bone Joint Surg Br. 2001 Apr;83(3):414-8. doi: 10.1302/0301-620x.83b3.11477.
In a prospective, controlled study, we measured the effect on cardiac output of the introduction of methylmethacrylate during hemiarthroplasty for displaced fractures of the femoral neck. We treated 20 elderly patients who were similar in age, height, weight and preoperative left ventricular function with either cemented or uncemented hemiarthroplasty. Using a transoesophageal Doppler probe, we measured cardiac output before incision and at six stages of the procedure: during the surgical approach, reaming and lavage of the femoral canal, the introduction of cement, the insertion of the prosthesis, and in reduction and closure. We found that before the cement was introduced, there was no difference in stroke volume or cardiac output (p > 0.25). Cementation produced a transient but significant reduction in cardiac output of 33% (p < 0.01) and a reduction in stroke volume of 44% (p < 0.02). The introduction of cement did not affect the heart rate or mean arterial pressure. There was no significant difference in cardiac function on insertion of the prosthesis. Standard non-invasive haemodynamic monitoring did not detect the cardiovascular changes which may account for the sudden deaths that sometimes occur during cemented hemiarthroplasty. The fall in stroke volume and cardiac output may be caused by embolism occurring during cementation, but there was no similar fall during reaming or insertion of the prosthesis.
在一项前瞻性对照研究中,我们测量了在股骨颈移位骨折半关节置换术中引入甲基丙烯酸甲酯对心输出量的影响。我们对20名年龄、身高、体重和术前左心室功能相似的老年患者进行了骨水泥型或非骨水泥型半关节置换术治疗。使用经食管多普勒探头,我们在切口前以及手术过程的六个阶段测量心输出量:手术入路、股骨扩髓和冲洗、骨水泥注入、假体植入以及复位和缝合时。我们发现,在注入骨水泥之前,每搏量或心输出量没有差异(p>0.25)。注入骨水泥使心输出量短暂但显著降低了33%(p<0.01),每搏量降低了44%(p<0.02)。注入骨水泥未影响心率或平均动脉压。假体植入时心功能无显著差异。标准的非侵入性血流动力学监测未检测到可能导致骨水泥型半关节置换术期间有时发生的猝死的心血管变化。每搏量和心输出量的下降可能是由于注入骨水泥时发生的栓塞引起的,但在扩髓或假体植入期间没有类似的下降。