预防腹部粘连不会干扰空肠吻合口愈合。
Prevention of abdominal adhesions does not interfere with jejunal anastomosis healing.
作者信息
Petroianu A, de Carvalho L B, Rocha K E, Barbosa A J
机构信息
Department of Surgery of the Medical School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Int J Surg Investig. 1999;1(2):149-56.
OBJECTIVE
To determine the prevention of adhesions interferes with the healing of jejunal anastomosis.
PARTICIPANTS
Twenty-five rats allocated into five groups.
INTERVENTIONS
Group 1- intraperitoneal injection of 12ml-1% sodium carboxymethylcellulose (SCMC). Groups 2-5- jejunal anastomosis. Groups 3 and 5- intraperitoneal SCMC-12 ml. The animals of the groups 2 and 4- only anastomosis. The rats of the groups 2 and 3- reopened on the 5th and those of groups 4 and 5 on the 21st postoperative days. Abdominal adhesions were graded and burst pressure of the anastomosis measured. Histological studies of anastomotic healing were performed.
RESULTS
Group 1 did not present any abnormality. Groups reopened on the 5th day did not differ in the burst pressures of the anastomosis and adhesion grades. The burst pressures in the groups reopened on the 21st postoperative day also did not differ. Histological patterns were similar in both groups on the 5th day, but on the 21st day, the rats treated with SCMC showed a maturer intestinal healing.
CONCLUSIONS
The prevention of adhesions not only did not interfere with jejunal anastomotic resistance, but also improved the intestinal healing in the rat.
目的
确定粘连预防对空肠吻合口愈合的影响。
参与者
25只大鼠分为五组。
干预措施
第1组——腹腔注射12毫升1%羧甲基纤维素钠（SCMC）。第2 - 5组——进行空肠吻合术。第3组和第5组——腹腔注射12毫升SCMC。第2组和第4组动物仅进行吻合术。第2组和第3组大鼠在术后第5天再次打开腹腔，第4组和第5组在术后第21天再次打开腹腔。对腹部粘连进行分级并测量吻合口的破裂压力。对吻合口愈合进行组织学研究。
结果
第1组未出现任何异常。在术后第5天再次打开腹腔的各组中，吻合口破裂压力和粘连分级无差异。术后第21天再次打开腹腔的各组中，破裂压力也无差异。两组在第5天的组织学模式相似，但在第21天，接受SCMC治疗的大鼠显示出更成熟的肠道愈合。
结论
粘连预防不仅未干扰空肠吻合口的抗张力，还改善了大鼠的肠道愈合。
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