沃纳综合征细胞对DNA交联药物敏感。 - Suppr

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超能文献

Werner syndrome cells are sensitive to DNA cross-linking drugs.

作者信息

Poot M, Yom J S, Whang S H, Kato J T, Gollahon K A, Rabinovitch P S

机构信息

Department of Pathology, University of Washington, Seattle, Washington 98195-7705, USA.

出版信息

FASEB J. 2001 May;15(7):1224-6. doi: 10.1096/fj.00-0611fje.

DOI:10.1096/fj.00-0611fje

PMID:11344095

Abstract

摘要

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Werner syndrome cells are sensitive to DNA cross-linking drugs.

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相似文献

Werner syndrome cells are sensitive to DNA cross-linking drugs.

FASEB J. 2001 May;15(7):1224-6. doi: 10.1096/fj.00-0611fje.

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease.

Nat Genet. 1998 Oct;20(2):114-6. doi: 10.1038/2410.

p53-mediated apoptosis is attenuated in Werner syndrome cells.

Genes Dev. 1999 Jun 1;13(11):1355-60. doi: 10.1101/gad.13.11.1355.

A twist in an early end.

Sci Aging Knowledge Environ. 2004 Jul 7;2004(27):nf63. doi: 10.1126/sageke.2004.27.nf63.

[The Werner syndrome gene, c-myc protein and senescence: subtle, have you said subtle?].

Bull Cancer. 2003 Aug-Sep;90(8-9):673.

Lack of WRN results in extensive deletion at nonhomologous joining ends.

Cancer Res. 2002 Jan 15;62(2):547-51.

[Molecular genetic analysis of Werner syndrome].

Nihon Ronen Igakkai Zasshi. 2001 Nov;38(6):766-8.

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

Nucleic Acids Res. 2000 Jun 15;28(12):2420-30. doi: 10.1093/nar/28.12.2420.

Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging.

Trends Genet. 1996 Aug;12(8):283-6. doi: 10.1016/0168-9525(96)30065-6.

Premature aging gene discovered.

Science. 1996 Apr 12;272(5259):193-4. doi: 10.1126/science.272.5259.193.

引用本文的文献

An overview of RecQ helicases and related diseases.

Aging (Albany NY). 2025 Jul 25;17(7):1881-1907. doi: 10.18632/aging.206291.

Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila.

PLoS Biol. 2025 Apr 22;23(4):e3003121. doi: 10.1371/journal.pbio.3003121. eCollection 2025 Apr.

Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer.

DNA Repair (Amst). 2025 May;149:103831. doi: 10.1016/j.dnarep.2025.103831. Epub 2025 Apr 3.

A Rare Presentation of Five Primary Cancers in a Patient With Werner Syndrome: A Case Report and Literature Review.

Cureus. 2025 Jan 16;17(1):e77534. doi: 10.7759/cureus.77534. eCollection 2025 Jan.

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein.

Int J Mol Sci. 2024 Jul 30;25(15):8300. doi: 10.3390/ijms25158300.

Methods of Detection and Mechanisms of Origin of Complex Structural Genome Variations.

Methods Mol Biol. 2024;2825:39-65. doi: 10.1007/978-1-0716-3946-7_2.

WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).

Cancer Treat Res. 2023;186:313-328. doi: 10.1007/978-3-031-30065-3_17.

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.

Sci Rep. 2021 Apr 27;11(1):9122. doi: 10.1038/s41598-021-88325-1.

Prevalence and Phenotypic Impact of Robertsonian Translocations.

Mol Syndromol. 2021 Mar;12(1):1-11. doi: 10.1159/000512676. Epub 2021 Feb 17.

Chromothripsis and Duplications as Underappreciated Genomic Gremlins.

Mol Syndromol. 2020 Dec;11(5-6):239-242. doi: 10.1159/000512565. Epub 2020 Dec 7.