Yen S S, Ehara Y, Siler T M
Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California 92037, USA.
J Clin Invest. 1974 Feb;53(2):652-5. doi: 10.1172/JCI107600.
The effect of estrogen on prolactin (PRL) release and gonadotropin suppression was assessed in six experiments performed on four hypogonadal women. Ethinyl estradiol at a dose of 1 microgram/kg per day induced a significant elevation of serum PRL levels within the 1st wk of treatment. There was a further rise until a plateau was reached in about 3-4 wk to levels of more than 3 times the initial concentration. This was accompanied by a pattern of increased episodic fluctuation. The corresponding serum luteinizing hormone and follicle-stimulating hormone fell progressively during the study period. These data indicate that a positive feedback relationship between estrogen and PRL release exists in humans.
在对四名性腺功能减退女性进行的六项实验中,评估了雌激素对催乳素(PRL)释放和促性腺激素抑制的作用。每天1微克/千克剂量的乙炔雌二醇在治疗的第1周内可使血清PRL水平显著升高。在大约3 - 4周达到平台期之前,PRL水平进一步上升,达到初始浓度的3倍以上。这伴随着阵发性波动增加的模式。在研究期间,相应的血清黄体生成素和卵泡刺激素逐渐下降。这些数据表明,人类体内雌激素与PRL释放之间存在正反馈关系。