长期术后干扰素-α治疗对丙型肝炎病毒相关肝细胞癌切除术后肝内复发的影响。一项随机对照试验。
Effects of long-term postoperative interferon-alpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial.
作者信息
Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Yamazaki O, Shiomi S, Tamori A, Oka H, Igawa S, Kuroki T, Kinoshita H
机构信息
Second Department of Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
出版信息
Ann Intern Med. 2001 May 15;134(10):963-7. doi: 10.7326/0003-4819-134-10-200105150-00010.
BACKGROUND
Interferon therapy decreases the incidence of hepatocellular carcinoma in patients with chronic hepatitis C.
OBJECTIVE
To evaluate effects of interferon-alpha on recurrence after resection of hepatitis C virus-related hepatocellular carcinoma.
DESIGN
Randomized, controlled trial.
SETTING
University hospital, medical center, and affiliated hospital in Osaka, Japan.
PATIENTS
30 men were randomly allocated after resection to the interferon-alpha group (n = 15) or the control group (n = 15).
INTERVENTION
Patients in the interferon-alpha group received interferon-alpha, 6 MIU intramuscularly daily for 2 weeks, then three times weekly for 14 weeks, and finally twice weekly for 88 weeks.
MEASUREMENTS
Recurrence rates after resection.
RESULTS
Recurrent tumors were detected in 5 patients in the interferon-alpha group and in 12 control patients. The recurrence rate was significantly lower in the interferon-alpha group than in the control group (P = 0.037).
CONCLUSION
Postoperative interferon-alpha therapy appears to decrease recurrence after resection of hepatitis C virus-related hepatocellular carcinoma.
背景
干扰素疗法可降低慢性丙型肝炎患者肝细胞癌的发病率。
目的
评估α干扰素对丙型肝炎病毒相关肝细胞癌切除术后复发的影响。
设计
随机对照试验。
地点
日本大阪的大学医院、医学中心及附属医院。
患者
30名男性患者在切除术后被随机分配至α干扰素组（n = 15）或对照组（n = 15）。
干预
α干扰素组患者接受α干扰素治疗，每日肌内注射6 MIU，共2周，然后每周3次，共14周，最后每周2次，共88周。
测量指标
切除术后的复发率。
结果
α干扰素组有5例患者检测到复发肿瘤，对照组有12例。α干扰素组的复发率显著低于对照组（P = 0.037）。
结论
术后α干扰素治疗似乎可降低丙型肝炎病毒相关肝细胞癌切除术后的复发率。
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