Hoerauf A, Mand S, Adjei O, Fleischer B, Büttner D W
Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany.
Lancet. 2001 May 5;357(9266):1415-6. doi: 10.1016/S0140-6736(00)04581-5.
Ivermectin is the drug used for mass chemotherapy of onchocerciasis within the WHO African Programme for Onchocerciasis Control. This approach aims to eliminate the disease as a public health problem but using one dose per year may not completely interrupt transmission since it does not suppress microfilaridermia thoroughly enough. Here we show that additional treatment with doxycycline, previously shown to sterilise adult female worms for a few months by depletion of symbiotic wolbachia endobacteria, significantly enhances ivermectin-induced suppression of microfilaridermia, rendering anti-wolbachia treatment a promising basis for blocking transmission by a drug-based approach.
伊维菌素是世界卫生组织非洲盘尾丝虫病控制规划中用于大规模化疗盘尾丝虫病的药物。这种方法旨在消除作为公共卫生问题的该疾病，但每年使用一剂可能无法完全阻断传播，因为它对微丝蚴血症的抑制不够彻底。我们在此表明，此前已证明强力霉素通过消耗共生沃尔巴克氏体细菌可使成年雌虫绝育数月，额外使用强力霉素治疗可显著增强伊维菌素对微丝蚴血症的抑制作用，使抗沃尔巴克氏体治疗成为基于药物方法阻断传播的一个有前景的基础。
